2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W1119955
    Cbz-TRIS-PDA trihydrochloride
    Cbz-TRIS-PDA (trihydrochloride) is a trifunctional compound containing a Cbz protecting group, which can be used in oligonucleotide synthesis.
    Cbz-TRIS-PDA trihydrochloride
  • HY-134382A
    7-CH-dADP trisodium
    7-CH-dADP (7-Deaza-2'-deoxyadenosine-5'-O-diphosphate) trisodium is a dehydroxylated and deaminated derivative of the nucleotide ADP.
    7-CH-dADP trisodium
  • HY-W439487
    7,9-Dimethylguanine
    7,9-Dimethylguanine is a modified nucleotide base that is a product of RNA degradation. The level of 7,9-Dimethylguanine in urine and serum can be used as a scoring indicator for the severity of alcoholic liver disease (ALD).
    7,9-Dimethylguanine
  • HY-171535
    LNA-UTP
    LNA-UTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-UTP
  • HY-134382
    7-CH-dADP
    7-CH-dADP (7-Deaza-2'-deoxyadenosine-5'-O-diphosphate) is a dehydroxylated and deaminated derivative of the nucleotide ADP.
    7-CH-dADP
  • HY-W048489
    DMT-2'-O-MOE-Tr
    DMT-2'-O-MOE-Tr (5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-thymidine) is a nucleoside analog containing a dimethoxytrityl (DMT) group, commonly used in the synthesis of nucleic acids.
    DMT-2'-O-MOE-Tr
  • HY-122524R
    7-Methylguanosine (Standard)
    		Inhibitor
    7-Methylguanosine (Standard) is the analytical standard of 7-Methylguanosine. This product is intended for research and analytical applications. 7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects.
    7-Methylguanosine (Standard)
  • HY-119499R
    6-Thioguanosine (Standard)
    6-Thioguanosine (Standard) is the analytical standard of 6-Thioguanosine. This product is intended for research and analytical applications. 6-Thioguanosine (6-Mercaptoguanosine), an active nucleoside, is an Azathioprine metabolite. 6-Thioguanosine has immunosuppressive effects.
    6-Thioguanosine (Standard)
  • HY-131806A
    3'-O-Ac-dTTP sodium
    3'-O-Ac-dTTP sodium is an acetylated derivative of nucleoside 5′-triphosphate.
    3'-O-Ac-dTTP sodium
  • HY-W784562
    5'-O-DMTr-2'-O-TBDMS-5-Me-U-3'-CE Phosphoramidite
    5'-O-DMTr-2'-O-TBDMS-5-Me-U-3'-CE Phosphoramidite is a nucleoside phosphoramidite monomer modified with protecting groups and can be used in RNA oligonucleotide synthesis.
    5'-O-DMTr-2'-O-TBDMS-5-Me-U-3'-CE Phosphoramidite
  • HY-W016011
    iBu-dG
    		98.0%
    iBu-dG (N2-Isobutyryl-2'-deoxyguanosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
    iBu-dG
  • HY-152834
    8-Methoxyadenosine
    8-Methoxyadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    8-Methoxyadenosine
  • HY-137674B
    isoGTP lithium
    isoGTP (Isoguanosine-5'-triphosphate) lithium is a GTP analog.
    isoGTP lithium
  • HY-W793155
    N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine
    N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a nucleoside analog that is structurally related to the natural nucleotide adenosine. N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is an activator of ribonucleotide reductase, which converts ribonucleosides to deoxyribonucleosides.
    N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine
  • HY-173582
    1-β-D-2'-Deoxyribofuranosyl-1,2,4-triazole-3-carboxamide-5'-O-triphosphate tetrasodium
    1-β-D-2'-Deoxyribofuranosyl-1,2,4-triazole-3-carboxamide-5'-O-triphosphate (tetrasodium) is a nucleotide analog. 1-β-D-2'-Deoxyribofuranosyl-1,2,4-triazole-3-carboxamide-5'-O-triphosphate (tetrasodium) can be used in the investigation of the sequence-saturated mutagenesis (SeSaM) method.
    1-β-D-2'-Deoxyribofuranosyl-1,2,4-triazole-3-carboxamide-5'-O-triphosphate tetrasodium
  • HY-152875
    5-Carboxymethyluridine
    5-Carboxymethyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Carboxymethyluridine
  • HY-W784612
    3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
    3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite is a nucleoside phosphoramidite monomer modified with a protecting group for use in RNA oligonucleotide synthesis.
    3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
  • HY-171527
    2′-OMe-ADP
    2′-OMe-ADP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-OMe-ADP
  • HY-Z15868
    5-Hydroxycytidine
    5-Hydroxycytidine is the RNA modified nucleoside that can be found in the 23S rRNA of bacteria E. coli. 5-Hydroxycytidine modifies at the C2501 site, exhibits a higher modification level in stationary cells. 5-Hydroxycytidine exhibits a higher modification level in radiation resistant Radius than in E. coli.
    5-Hydroxycytidine
  • HY-174162A
    2'-O-Methylguanosine-5'-O-triphosphate sodium
    2'-O-Methylguanosine-5'-O-triphosphate sodium (2'-Methyl GTP sodium), a methylated derivative of Guanosine 5'-triphosphate (HY-W010737), is a HCV NS5B RNA-dependent RNA polymerase inhibitor. 2'-O-Methylguanosine-5'-O-triphosphate sodium is a nucleotide competitor of GTP and acts as a chain terminator to inhibit RNA synthesis. 2'-O-Methylguanosine-5'-O-triphosphate sodium can be used for HCV infections research.
    2'-O-Methylguanosine-5'-O-triphosphate sodium